Top Active Series A Investors & VCs Funding Startups in the US in 2025

Last update to database: February 16, 2026

Leading Growth-Stage Investors & Venture Capital Firms Funding Series A Startups Across the US

Series A funding continues to define a critical growth stage for US startups in 2025, helping founders scale proven products and expand into new markets. The top active Series A investors and VCs funding startups in the US are backing companies in AI, SaaS, fintech, health tech, and climate tech—sectors attracting the most venture capital activity this year.


These investors specialize in transforming early traction into sustainable growth, providing the capital, strategic guidance, and networks startups need to reach Series B and beyond. Many are headquartered in San Francisco, New York, Austin, and Boston, while others are global firms actively funding Series A rounds across the United States.


Our database highlights investors currently funding and supporting Series A startups in the US. Updated weekly, it offers founders, analysts, and business-development teams real-time visibility into who’s actively investing at the growth-stage level across America.

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Comprehensive Database of Active Series A Investors & VCs Funding US Startups – Updated Weekly

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Investor Name
Industry Focus Recent Investments Recent Investment Date Check Size Stage Focus Geography Focus Company Headquarters Firm Type Portfolio Size Portfolio Highlights Co-Investor Network
OUROBOROS Biotechnology, Business & Professional Services Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A United States, New York New York, New York, United States Private Equity 2 Subscribe to Unlock Subscribe to Unlock Unknown
Castle Island Ventures Blockchain & Cryptocurrency, Financial Services & FinTech, Artificial Intelligence, SaaS & Software, Data & Analytics Subscribe to Unlock Subscribe to Unlock January, 2026 $100k-$500k Seed, Series A United States Boston, Massachusetts, United States Venture Capital 72 Subscribe to Unlock Subscribe to Unlock Andreessen Horowitz, Union Square Ventures, Polychain Capital, Paradigm
Alt Capital Financial Services & FinTech, Business & Professional Services Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A United States, Colorado, Kansas, Missouri, Nebraska, Texas Kansas City, Missouri, United States Other 20 Subscribe to Unlock Subscribe to Unlock Unknown
Maveron E-Commerce & Retail, Consumer Brands (part of E-Commerce & Retail), Financial Services & FinTech, Health Care & Wellness, SaaS & Software Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A United States, San Francisco, Seattle, New York San Francisco, California, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Unknown
Coinbase Blockchain & Cryptocurrency, Financial Services & FinTech, Apps & Platforms, Data & Analytics, SaaS & Software Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D United States San Francisco, California, United States Corporate VC 461 Subscribe to Unlock Subscribe to Unlock Pantera Capital, Andreessen Horowitz, Polychain Capital, Dragonfly, Alameda Research
StageDotO SaaS & Software, Financial Services & FinTech, Information Technology Subscribe to Unlock Subscribe to Unlock January, 2026 $500k-$1M Angel, Pre-Seed, Seed, Series A, Series B United States Boise, Idaho, United States Venture Capital 10 Subscribe to Unlock Subscribe to Unlock Unknown
Stead Impact Health Care & Wellness, Biotechnology, Artificial Intelligence, SaaS & Software, Data & Analytics Subscribe to Unlock Subscribe to Unlock January, 2026 $500k-$1M Pre-Seed, Seed, Series A North America United States Venture Capital 9 Subscribe to Unlock Subscribe to Unlock Unknown
Ridge Ventures SaaS & Software, Apps & Platforms, Information Technology, Business & Professional Services, Marketing, Advertising & Sales Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A United States, San Francisco San Francisco, California, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Unknown
Variant Blockchain & Cryptocurrency, Web & Internet Platforms, Financial Services & FinTech, SaaS & Software, Social & Lifestyle Networks Subscribe to Unlock Subscribe to Unlock February, 2026 $250k-$500k Pre-Seed, Seed, Series A United States New York, New York, United States Venture Capital 50 Subscribe to Unlock Subscribe to Unlock Unknown
Data Point Capital SaaS & Software, Artificial Intelligence, Financial Services & FinTech, E-Commerce & Retail, Data & Analytics Subscribe to Unlock Subscribe to Unlock January, 2026 $500k-$1M Series A, Series B United States Boston, Massachusetts, United States Venture Capital 67 Subscribe to Unlock Subscribe to Unlock Blu Venture Investors, FINTOP Capital, Osage Venture Partners, Bullpen Capital, Forum Ventures
Next Coast Ventures Financial Services & FinTech, Venture Capital, SaaS & Software, Health Care & Wellness, Apps & Platforms Subscribe to Unlock Subscribe to Unlock January, 2026 $1M–$10M Seed, Series A, Series B, Growth United States, Austin, Texas Austin, Texas, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Renaissance Venture Capital, de Anda Capital, Unknown, Unknown
Accel SaaS & Software, Information Technology, Financial Services & FinTech, Health Care & Wellness, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D United States, United Kingdom, India, China Palo Alto, California, United States Venture Capital 1133 Subscribe to Unlock Subscribe to Unlock Y Combinator, Sequoia Capital, Tiger Global Management, Insight Partners, Lightspeed Venture Partners
Capital Eleven Enterprise Applications, Financial Services & FinTech, Retail, Real Estate, SaaS & Software Subscribe to Unlock Subscribe to Unlock January, 2026 $1M–$10M Seed, Series A United States Meridian, Idaho, United States Venture Capital 50 Subscribe to Unlock Subscribe to Unlock Forum Ventures, Handshake Ventures, Kickstart Fund, R-Squared Ventures
Vintage Investment Partners Information Technology, SaaS & Software, Artificial Intelligence, Financial Services & FinTech, Data & Analytics Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Series A, Series B, Series C, Series D United States, Europe, Israel, Canada Herzilyah Pituach, Tel-Aviv District, Israel Venture Capital 6000 Subscribe to Unlock Subscribe to Unlock Unknown
BoxGroup FinTech, SaaS & Software, Marketplaces, GreenTech & Sustainability, Developer Tools Subscribe to Unlock Subscribe to Unlock February, 2026 $500k–$1M Pre-Seed, Seed, Series A United States, New York, San Francisco New York, New York, United States Venture Capital 872 Subscribe to Unlock Subscribe to Unlock Unknown
TLV Partners Cyber Security & Privacy, Data & Analytics, Artificial Intelligence, Financial Services & FinTech, Biotechnology Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A Israel Tel Aviv, Israel Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Munich RE, Nvidia, Intel, Rubrik
Menlo Ventures Artificial Intelligence, Biotechnology, Cyber Security & Privacy, Financial Services & FinTech, SaaS & Software Subscribe to Unlock Subscribe to Unlock February, 2026 $1M–$10M Seed, Series A, Series B United States, Canada Menlo Park, California, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Anthropic
Lerer Hippeau Apps & Platforms, SaaS & Software, Financial Services & FinTech, Health Care & Wellness, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock February, 2026 $100k-$1M Pre-Seed, Seed, Series A, Series B, Series C, Series D United States, New York New York City, New York, United States Venture Capital 350 Subscribe to Unlock Subscribe to Unlock Union Square Ventures, First Round Capital, Accel, Thrive Capital, Greycroft
Bessemer Artificial Intelligence, Biotechnology, Cyber Security & Privacy, Financial Services & FinTech, SaaS & Software Subscribe to Unlock Subscribe to Unlock February, 2026 $1M–$10M Seed, Series A, Series B, Series C North America, Europe, Israel, India San Francisco, California, United States Venture Capital 390 Subscribe to Unlock Subscribe to Unlock Unknown
M12 Microsoft's Venture Fund Artificial Intelligence, Cloud Infrastructure, Cyber Security & Privacy, SaaS & Software, Gaming Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C United States Phoenix, Arizona, United States Corporate VC 100 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Accel, Insight Partners, Tiger Global Management
Omega Funds Biotechnology, Health Care & Wellness, Life Sciences Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B United States, Europe Boston, Massachusetts, United States Venture Capital 52 Subscribe to Unlock Subscribe to Unlock Unknown
Andera Partners Life Sciences & Biotechnology, Financial Services & FinTech, Industrial & Manufacturing, Energy & Ecological Transition, Software & Technology Subscribe to Unlock Subscribe to Unlock January, 2026 $10M-$20M Growth (mid to late stage), Expansion, Mezzanine France, Europe, United States Paris, Île-de-France, France Private Equity 350 Subscribe to Unlock Subscribe to Unlock Unknown
SOSV Biotechnology, Hardware, Artificial Intelligence, Food & Drink, GreenTech & Sustainability Subscribe to Unlock Subscribe to Unlock February, 2026 $500k-$1M Pre-Seed, Seed, Series A North America, Asia, Europe Princeton, New Jersey, United States Venture Capital 1000 Subscribe to Unlock Subscribe to Unlock Unknown
Forbion Biotechnology, Health Care & Wellness, AgriTech & Farming, GreenTech & Sustainability, Science & Engineering Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Pre-Seed, Seed, Series A, Series B, Series C Europe, United States Naarden, The Netherlands Venture Capital 90 Subscribe to Unlock Subscribe to Unlock BioGeneration Ventures, European VC firms, US biotech VCs
General Catalyst Artificial Intelligence, Health Care & Wellness, Financial Services & FinTech, SaaS & Software, Enterprise Subscribe to Unlock Subscribe to Unlock February, 2026 $1M–$10M Seed, Series A, Series B, Growth North America, Europe, Asia Cambridge, Massachusetts, United States Venture Capital 800 Subscribe to Unlock Subscribe to Unlock GC Famiglia (community of CEOs, founders, partners, policymakers)
Owl Ventures EdTech and Training, SaaS & Software, Artificial Intelligence, Business & Professional Services Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A, Series B, Series C United States, Europe, Asia San Francisco, California, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, New Enterprise Associates, GSV Ventures, Reach Capital
Catapult Ventures Artificial Intelligence, Robotics, Internet of Things, Hardware, Aerospace Subscribe to Unlock Subscribe to Unlock January, 2026 $250k-$500k Pre-Seed, Seed United States, Silicon Valley Los Altos, California, United States Venture Capital 25 Subscribe to Unlock Subscribe to Unlock Unknown
Friends & Family Capital SaaS & Software, Information Technology, Financial Services & FinTech, Business & Professional Services Subscribe to Unlock Subscribe to Unlock January, 2026 $500k-$1M Seed, Series A, Series B, Series C, Series D United States, Silicon Valley Menlo Park, California, United States Venture Capital 75 Subscribe to Unlock Subscribe to Unlock Unknown
DNX Ventures SaaS & Software, Cyber Security & Privacy, Artificial Intelligence, GreenTech & Sustainability, Hardware Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A United States, Japan San Mateo, California, United States Venture Capital 153 Subscribe to Unlock Subscribe to Unlock Mitsubishi UFJ Capital, Shoko Chukin Bank, JIC Venture Growth Investments
Founders Fund Artificial Intelligence, Biotechnology, Hardware, SaaS & Software, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D United States San Francisco, California, United States Venture Capital 90 Subscribe to Unlock Subscribe to Unlock Unknown
Madrona Artificial Intelligence, SaaS & Software, Health Care & Wellness, Apps & Platforms, Data & Analytics Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C United States, Seattle, Silicon Valley Seattle, Washington, United States Venture Capital 90 Subscribe to Unlock Subscribe to Unlock Andreessen Horowitz, First Round Capital, Floodgate, BAMCAP
Kompas VC Manufacturing, Built Environment, Sustainability, Advanced Materials, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A Europe, United States, Israel H√∏rsholm, Denmark Venture Capital 25 Subscribe to Unlock Subscribe to Unlock M Ventures, Maniv Mobility, Lightrock, Hitachi Ventures, Aegis Ventures
CRV SaaS & Software, Financial Services & FinTech, Information Technology, Apps & Platforms, Enterprise Software Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B United States Palo Alto, California, United States Venture Capital 750 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Accel, Benchmark, Greylock Partners
Population Health Partners Biotechnology, Health Care & Wellness, SaaS & Software, Data & Analytics, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Pre-Seed, Seed, Series A, Series B, Series C United States San Francisco, California, United States Venture Capital 9 Subscribe to Unlock Subscribe to Unlock GV, 3ARCH Venture Partners, Forbion, Maverick Capital, The Invus Group
Platanus Financial Services & FinTech, SaaS & Software, Artificial Intelligence, Health Care & Wellness, E-Commerce & Retail Subscribe to Unlock Subscribe to Unlock January, 2026 $100k-$250k Pre-Seed, Seed Latin America Mexico City, Ciudad de México, Mexico Venture Capital 90 Subscribe to Unlock Subscribe to Unlock Unknown
SR One Capital Management Biotechnology, Health Care & Wellness, Therapeutics, Pharmaceutical, Life Sciences Subscribe to Unlock Subscribe to Unlock January, 2026 $10M-$20M Series A, Series B, Series C, Series D United States, United Kingdom, Israel, Canada, Switzerland Redwood City, California, United States Corporate VC 103 Subscribe to Unlock Subscribe to Unlock Roche Venture Fund, OrbiMed, Sofinnova Partners, Polaris Partners, Lilly Ventures
Vida Ventures Biotechnology, Health Care & Wellness, Science & Engineering, Pharmaceuticals, Therapeutics Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Seed, Series A, Series B, Series C United States, Boston, Los Angeles, New York Los Angeles, California, United States Venture Capital 35 Subscribe to Unlock Subscribe to Unlock Johnson & Johnson, Bayer, AstraZeneca, Merck
Washington Harbour Technology, Media, Communications, Financial Services & FinTech, Business & Professional Services, Cyber Security & Privacy Subscribe to Unlock Subscribe to Unlock January, 2026 $1M-$10M Series B, Series C, Series D United States Arlington, Virginia, United States Private Equity 55 Subscribe to Unlock Subscribe to Unlock Unknown
SignalFire Health Care & Wellness, SaaS & Software, Cyber Security & Privacy, Artificial Intelligence, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D United States, San Francisco San Francisco, California, United States Venture Capital 600 Subscribe to Unlock Subscribe to Unlock Unknown
Footwork Consumer technology, Enterprise technology, SaaS & Software, Artificial Intelligence, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A United States, San Francisco San Francisco, California, United States Venture Capital 21 Subscribe to Unlock Subscribe to Unlock Unknown
Andreessen Horowitz Artificial Intelligence, Biotechnology, Blockchain & Cryptocurrency, Financial Services & FinTech, Gaming Subscribe to Unlock Subscribe to Unlock February, 2026 $500k–$1M Pre-seed, Seed, Series A, Series B, Growth, Late-stage North America, United States Menlo Park, California, United States Venture Capital 1000 Subscribe to Unlock Subscribe to Unlock Thrive Capital, General Catalyst, Alumni Ventures, Sequoia Capital, Accel
Sequoia Capital Energy, Financial Services & FinTech, Health Care & Wellness, Information Technology, SaaS & Software Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Growth United States, China, India Menlo Park, California, United States Venture Capital 1605 Subscribe to Unlock Subscribe to Unlock Lightspeed Venture Partners, In-Q-Tel, 8VC, Pantera Capital, Kleiner Perkins
Lightspeed Artificial Intelligence, Cyber Security & Privacy, Biotechnology, SaaS & Software, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock February, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D United States, Europe, India, Israel, Southeast Asia Menlo Park, California, United States Venture Capital 500 Subscribe to Unlock Subscribe to Unlock Sequoia, Andreessen Horowitz, Accel, Greylock, Benchmark
Strobe Ventures Financial Services & FinTech, Blockchain & Cryptocurrency, SaaS & Software, Business & Professional Services Subscribe to Unlock Subscribe to Unlock December, 2025 $500k-$1M Seed, Series A United States, New York New York City, New York, United States Venture Capital 34 Subscribe to Unlock Subscribe to Unlock BlockTower Capital, Coinbase Ventures, Andreessen Horowitz, FJ Labs, Fabric Ventures
Neman Ventures SaaS & Software, Food & Drink, Logistics & Transportation, Financial Services & FinTech, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock December, 2025 $500k-$1M Seed, Series A United States Miami, Florida, United States Family Office 40 Subscribe to Unlock Subscribe to Unlock Andreessen Horowitz, Sequoia Capital, Accel
FundersClub SaaS & Software, Blockchain & Cryptocurrency, Logistics & Transportation, Artificial Intelligence, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock December, 2025 $100k-$250k Seed, Series A United States, Silicon Valley San Francisco, California, United States Venture Capital 410 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Kleiner Perkins, Khosla Ventures, IVP
Full In SaaS & Software, Business & Professional Services, Health Care & Wellness, Information Technology, Consumer Products & Services Subscribe to Unlock Subscribe to Unlock December, 2025 $1M-$10M Series A, Series B, Series C United States, Australia, Europe, Israel New York, New York, United States Private Equity 14 Subscribe to Unlock Subscribe to Unlock Lion Capital, 3 other unnamed investors
Elephant Enterprise Software, Consumer Internet, Mobile Technology, SaaS & Software, Digital Media Subscribe to Unlock Subscribe to Unlock December, 2025 $1M-$10M Series A, Series B, Series C United States, Boston Boston, Massachusetts, United States Venture Capital 31 Subscribe to Unlock Subscribe to Unlock Alumni Ventures, Barclays Ventures, Bertelsmann Digital Media Investments, K20 Fund, Techstars Ventures
Rethink Impact LP Health Care & Wellness, Education & Training, GreenTech & Sustainability, SaaS & Software, Social & Lifestyle Networks Subscribe to Unlock Subscribe to Unlock December, 2025 $1M-$10M Seed, Series A, Series B, Series C United States New York, New York, United States Venture Capital 46 Subscribe to Unlock Subscribe to Unlock University Endowments, Foundations, Individual Investors
Pace Ventures Health Care & Wellness, GreenTech & Sustainability Subscribe to Unlock Subscribe to Unlock December, 2025 $500k-$1M Pre-Seed, Seed Europe, United States Berlin, Germany Venture Capital 20 Subscribe to Unlock Subscribe to Unlock Unknown

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